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Cardiovascular diseases (CVD) remain the leading therapeutic category within the worldwide pharmaceutical market, generated revenues of $351.8 billion in 2003. It is the leading cause of death and morbidity in industrialized nations, accounting for about 40% of all deaths and resulting in17 million deaths occurring globally each year. The range of conditions within cardiovascular disease is wide, the best known forms of CVD, coronary heart disease and cerebrovascular disease, accounted for nearly two thirds of all CVD deaths. The principle aims of cardiovascular therapies are to reduce morbidity and mortality from heart attacks, strokes and other blood vessel related disease.
Dermatology is a diverse specialty encompassing disorders and diseases of the skin, mucous membrane, hair and nails and a number of sexually transmitted diseases. The Dermatology market was calculated be to be worth over $7500m, a growth of over 5 per cent form the previous year (Visiongain). Dermatology is a diverse term, encompassing disorders and diseases of the skin, mucous membrane, hair and nails and a number of sexually transmitted disease manifesting as acne, warts, multiple inflammatory dermatoses, skin cancers, autoimmune diseases, occupational dermatoses and contact dermatitis. The major segment of this market is dermatitis with over 27 per cent of the market. However, Uriticaria and Acne also have significant shares of the market. The treatment ranges from performing a wide variety of surgical procedures (e.g., excisions, sclerotherapy, laser surgery, liposuction, hair transplants and tissue augmentation therapies) to the care of normal skin, prevention of skin diseases and cancers and treatment of photoaging skin. The major segment of this market is dermatitis with over 27 per cent of the market. However, Uriticaria and Acne also have significant shares of the market.
Endocrine diseases such as diabetes are on the increase as populations age and become more overweight. In fact, the global market is expected to double over the next five years and generate revenues totaling just under US$76.1 billion Over 75 million Americans suffer from some type of endocrine disorder and/or related health issue, placing a substantial and rising burden on the US healthcare system.Â It has been estimated that diabetes and its complications alone utilize approximately 5% to 10% of the nationâ??s health budget.
As many as 70 million Americans are affected by kidney and urological diseases, and they are widely perceived to represent one of the leading medical crises currently affecting the US.The worldwide urinary incontinence therapeutics market is estimated at over US$2.11 billion in 2005 and is expected to reach more than US$3.69 billion by 2010.
Infectious disease is currently the leading cause of death worldwide, ranking amongst the top 10 causes of death in the US alone. The global anti-infectives market is valued at around $30 billion and continues to grow - with more than 30 new infectious diseases have emerged over the past 20 years, including AIDS. The HIV epidemic continues to outpace global response - three million people died of AIDS in 2003; there were another five million new infections with an estimated 38 million being infected by HIV worldwide - equating to approximately 14,000 cases every day. Hepatitis affects over 500 million people worldwide and in the US alone one in 10 people are or have been affected with liver and biliary diseases. Hepatitis B is 100 times more infectious than HIV. Tuberculosis (TB) has re-emerged as a major global threat - the HIV pandemic and various strains of TB are now resistant to major anti-TB drugs. Two million people die every year from TB.
With a market value of US$14.3 billion in 2005, and a predicted revenue of US$25.3 billion in 2009, musculoskeletal treatments are part of a dynamic and swiftly evolving market sector. With the number of individuals over the age of 50 is expected to have doubled by 2020, the growing prevalence of obesity and sedentary lifestyles the market looks set to increase steadily. Indeed, the North American orthopaedics market was worth US$23.7 billion for full-year 2003 and is set to increase to US$41.7 billion by 2009.
Neurological disorders are one of the leading causes of death worldwide, ranking among the top five in the US alone. Over 1.5 billion people worldwide, 127 million people in Europe and 100 million individuals in North America suffer from a debilitating neurological or psychiatric illness. Alzheimerâ??s disease alone is the fourth leading cause of death in the US, with an estimated 4.5 million affected and 100,000 dying from Alzheimerâ??s per year. With a growing ageing population, increasing life expectancy and a high unmet clinical need, brain research, brain diseases, diseases of the central nervous system (CNS) and indeed mental health are set to remain high on the future health agenda.
The one-in-three chance of being diagnosed with some type of cancer make cancer is the leading cause of morbidity and mortality in the developed world and is increasing in the developing world. In Western Europe, 24.9% of all deaths are attributed to cancer. In the Americas, around 18.4% of registered deaths are due to cancer; in the USA the proportion is 22.8% (2002). In 2005, around 1.4 million people in the USA were diagnosed with cancer and 570,280 will died from the disease. Of these, it is estimated that 16.9% were diagnosed with prostate cancer, 15.5% with breast cancer, 12.6% with cancer of the bronchus and lung, and 10.6% with colorectal cancer. The available treatment options for cancer vary according to the cancer site, disease progression, age and health of the patient. Treatment may include surgery, radiotherapy, chemotherapy and/or hormone therapy.
Respiratory Disease disabled
Respiratory disease (including asthma, chronic obstructive pulmonary disease (COPD), obstructive sleep apnea (OSA), and cystic fibrosis (CF)) is a significant public health issue in the US. The number of individuals suffering from respiratory disease worldwide is estimated to exceed one billion, with approximately 35 million individuals living with a chronic respiratory disease in the US alone. 235,000 deaths occur each year in the US. The respiratory market generated revenues of $25.5 billion in 2004 in the seven major pharmaceutical markets.
The inability of the brain to correctly process information brought in by the senses - where the senses fail to develop and work together; touch, sight, sound, taste, and body movement. These conditions include anosmia (loss of the sense of smell), ageusia (loss of the sense of taste) and dysgeusia (distorted sense of taste).
Certain population groups defined by race, gender, age, lifestyle and concomitant medical conditions experience greater morbidity and mortality when faced with certain disease. For example, South Asians, African Americans, and Hispanics, carry a disproportionately larger burden of cardiovascular disease manifested as coronary artery disease, cerebrovascular disease, and hypertension.